Active ingredient against bacterial toxin
// Medicine and Pharmaceuticals // Therapy and Active Ingredients
Ref-Nr: 16757
Abstract
Clostridium difficile is an anaerobic, Gram-positive, endospore-forming rod bacterium. It is one of the most common hospital germs. In healthy people Clostridium difficile is a harmless intestinal bacterium. If competing species of the normal intestinal flora are suppressed by antibiotics, Clostridium difficile can multiply and produce toxins (Toxin A/TcdA and Toxin B/TcdB), which can lead to life-threatening diarrhoea (e.g. diarrhoea).
Fig. 1: New epitope (red) in TcdB toxin
background
The standard therapies for Clostridium difficile infection (CDI) include the antibiotics metronidazole and vancomycin. The therapy is not effective because relapses occur in 25-40% of cases.
Motivation
The therapeutic antibody Bezlotoxumab is used to prevent relapses. It can only reduce the relapse rate by 40%.Innovation / Solution
In order to avoid CDI or to reduce the relapse rate, a new epitope on the toxin B (TcdB) of Clostridium difficile could be described by the recombinant antibodies VIF087-A10 and SH1429-B1. These protein segments, which contain the neutralizing epitopes, can be used as vaccine as well as for the generation of therapeutic antibodies against TcdB. The therapeutic antibodies can be used alone or in combination with other neutralizing antibodies (e.g. Bezlotoxumab).Benefits
Protein fragments comprising the epitope/peptide can be used as a vaccine to prevent CDI or reduce the relapse rate.
The epitope/peptide can be used for the generation of therapeutic and diagnostic antibodies.
Newly generated therapeutic antibodies can be used alone or in combination with other neutralizing antibodies (e.g. Bezlotoxumab) to prevent CDI or reduce the relapse rate.
fields of application
The field of application of the service invention is the field of medicine and pharmacy or the special field of active substances against bacterial hospital germs that are difficult to combat.You can close this window. You can find your search results in the previous window
